ADJ

big, broad, considerable, dramatic, enormous, great, huge, large, major, profound, radical, real, sharp, substantial, vast, wide
A little extra care makes a big difference. I noticed a real difference in his attitude
basic, essential, fundamental
crucial, important, key, significant
clear, distinct, marked, notable, noticeable, obvious, striking
minor, slight, subtle
national, regional
age, class, cultural, ethnic, gender, genetic, physical, psychological, racial, sex, social
historical, ideological, political
temperature, time
What's the time difference between London and Tokyo?

VERB + DIFFERENCE

make
The new central heating has made an enormous difference to the house. What difference does it make if he doesn't have a car?
mean
One tiny mistake when you're climbing could mean the difference between life and death
exaggerate, emphasize, focus on, highlight, stress, underline
We should be focusing on what we have in common rather than emphasizing our differences
appreciate, be aware of, feel, know, notice, perceive, see, spot, tell
Only an expert would know the difference between the male and the female. Can you spot the difference between these two photos? It's difficult to tell the difference between butterflies and moths
explain, illustrate
examine, explore, look at
The study explores the differences between the way girls and boys talk
show
The questionnaire showed vast differences in what kind of product people want
reflect
Our different attitudes to life reflect the differences in our backgrounds

DIFFERENCE + VERB

be, lie
The difference lies in the way the fruit is prepared
arise (from sth), exist
The differences in size arise from the amount of sunshine each plant gets

PREP

~ between
There's a big difference between reading about skiing and doing it yourself
~ from
He was very aware of his difference from the other children
~ in
The difference in price is not very significant
~ of
a crucial difference of emphasis
~ with
There is one key difference with the earlier version of the software. The difference with this information service is that it's free

PHRASES

a … with a difference
If you want a holiday with a difference, come to Iceland
all the difference in the world
There's all the difference in the world between choosing to do something and being forced to do it
a great deal of/a lot difference
The extra money will make a lot of difference to us
make all the difference
Just five minutes' exercise a day could make all the difference
no difference/not much difference
There's not much difference between baseball and softball

VERB + DIFFERENCE

pay
If you decide you would prefer the more expensive model, you can bring this one back and pay the difference
make up
He hadn't got quite enough money, but his aunt agreed to make up the difference
pocket
He sold the car for more than he'd paid and pocketed the difference
split
(figurative) I wanted to leave early and Ian wanted to leave late, so we split the difference and left at noon

ADJ

irreconcilable, major, serious, sharp
minor, slight
outstanding
This round of talks aims to resolve the outstanding differences between the two sides

VERB + DIFFERENCE

have
They have had some minor differences, but in general they get on well together
make up, patch up, put aside, reconcile, resolve, settle
We're going to get the two sides together to see if they can't settle their differences

DIFFERENCE + VERB

arise, emerge, occur
Differences may arise when the young people do not have the same expectations as their parents
remain
Although the talks were generally successful, differences remain between the groups

PREP

~ as to/over
There were some differences as to how to deal with the crisis

PHRASES

a difference of opinion
She and Luke had a difference of opinion over how much money they should spend
have your differences
Like any married couple, we have our differences