ADV

carefully, with care
A label on the crate read: 'Handle with care'
carelessly
Garden tools can be hazardous if carelessly handled
roughly
Many of the prisoners were roughly handled; some were killed

ADV

competently, efficiently, properly, skilfully, successfully, well
I think you handled that situation very well
badly
carefully, delicately
This issue may need to be handled carefully
easily
Her next question was not so easily handled
routinely
The library routinely handles a wide variety of enquiries

VERB + HANDLE

be able/unable to, can/could, know how to
This was a problem that I just couldn't handle. She knew how to handle publicity
be designed to, be equipped to
He wasn't mentally equipped to handle this situation
learn how to
be easy to
be difficult to, be hard to
Large meetings are notoriously less productive and more difficult to handle

PREP

with
She handled the crisis with total assurance